Numerous studies have shown that ACT is successful for treating depression, particularly for those who struggle with chronic, treatment-resistant, or comorbid conditions.

• Meta-analyses and systematic reviews

• • A 2016 meta-analysis (A-Tjak et al.) reviewed 39 randomized controlled trials (RCTs) and found that ACT notably reduces symptoms of depression and has comparable effects to Cognitive Behavioral Therapy (CBT).
  • A 2020 systematic review (Gloster et al.) discovered that ACT improves psychological flexibility, which is key in managing depressive symptoms.

• Comparison with CBT
  
  

• • Studies suggest that ACT and CBT show similar effectiveness in reducing depression, but ACT may have an edge in promoting long-term acceptance and psychological flexibility, reducing relapse rates.

• Long-term benefits

• • Unlike traditional therapies that focus on symptom reduction, ACT helps build sustained toughness by teaching to accept distress and commit to important actions despite the symptoms.