Psychotic depression requires more intensive treatment than non-psychotic depression.
The most successful approach is usually a combination of:
- Antidepressant + antipsychotic medication
E.g., an SSRI like fluoxetine + an antipsychotic like olanzapine.
- Electroconvulsive therapy (ECT)
Very effective and often faster-acting in severe or treatment-resistant cases.
- Psychotherapy
CBT and supportive therapy can help once symptoms stabilize.
Monotherapy with an antidepressant alone is not recommended, as it might intensify the psychosis or be ineffective.
–> My exhaustive guide about psychotic depression can be found here.
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