What causes premenstrual dysphoric depression?

Kevin Mangelschots·22/07/2025·0 comments

The exact cause isn’t fully understood, but it’s believed to be related to:

  • Hormonal fluctuations during the menstrual cycle (some are extremely sensitive to normal changes in estrogen and progesterone).
  • Serotonin dysregulation: Many women with PMDD have altered serotonin activity, a neurotransmitter closely tied to mood regulation.

–> My detailed premenstrual dysphoric disorder guide can be found here.

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Kevin

Hi there, I’m Kevin Mangelschots! A little more about myself: - I'm 33 years old. - I’m a registered, licensed, and practicing therapist with a bachelor’s degree in occupational therapy. - Currently practicing at a rehabilitation center located in Belgium. Longtime fitness and gaming enthusiast. - Turned towards psychology, philosophy, mental health, and self-improvement to improve my chronic depression. - My goal is to share evidence-based information with the world that I know is helpful and useful to improve depression and overall well-being. In short, I’m just a guy trying to make sense of the world by thinking about ideas, studying psychology, philosophy, and mental and physical health. I strive to apply my degree in healthcare (occupational therapy) to explain concepts as clearly as possible, based on current research findings.

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